Feeling Tired But Wired?

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Do you, despite feeling tired and perhaps even exhausted, still struggle to sleep and shut down at night? Or do you wake back up frequently? It’s a common complaint from thyroid patients and the answer could lie in your adrenals. 

Adrenal Fatigue (note: it is more accurately referred to as hypothalamic-pituitary axis dysfunction) is a condition that many thyroid patients experience alongside their hypothyroidism. In Thyroid Pharmacist Izabella Wentz’s experience, adrenal dysfunction is present in 90% of us with autoimmune hypothyroidism, but I bet most of you reading this have no clue if you’re one of them!

The adrenal glands sit atop the kidneys, and are part of the endocrine system, just like the thyroid. They handle many hormones that are important for a lot of bodily processes, such as responding to stress. This where cortisol, the culprit behind many sleeping issues, comes in.

There are two recognised conditions in conventional medicine in association with extreme dysfunctioning of the adrenal glands: Addison’s, which is a long term condition whereby the adrenal glands do not produce enough cortisol and Cushing’s, which is the opposite – where the adrenals produce often dangerously high levels of the hormone.

Adrenal fatigue is a condition well recognised within functional and holistic medicine, where the adrenal glands produce too much or too little cortisol, though not to the extent of Cushing’s or Addison’s, but abnormal enough that it causes symptoms and issues all the same. It works on the idea that there is a scale rather than just extremes.

Cortisol is very important when it comes to our energy levels. It is at its highest (or at least should be) in the morning to wake us up, gradually declining as the day goes on, before it reaches its lowest point in the evening, so that we’re ready for sleep. But when someone has adrenal fatigue, their cortisol levels don’t follow this pattern. Instead, their cortisol could be high when it should be low and low when it should be high, creating issues with sleep cycles for example.

So, how do you know if you have it?

Order or ask for a 24 hour saliva test, testing your cortisol levels at four key points of the day, to find out if you have adrenal fatigue. If your doctor won’t do this, you can very simply order it yourself and complete it at home. A UK test can be found here and an international test here. Most doctors will only test it with a one time urine or blood sample, which is not as accurate. Four samples taken over a 24 hour day show how your rhythm of cortisol production is working and if you have that typical rise and fall pattern explained above. It should be highest in the morning, tailing off throughout the day. Only four saliva samples taken in one day will tell you this accurately.

However there are many more symptoms to adrenal fatigue than just sleep disruptions and fatigue. Check them all out here.

And how do I fix it?

As well as herbal and vitamin supplements, usually lifestyle and dietary changes also need to be made, in order to recover from adrenal fatigue, but it’s very much individual to each person. Lots of info on this can be found in James Wilson’s book but I’d also recommend consulting a medical practitioner who recognises adrenal fatigue, such as a functional doctor, functional medicine practitioner or naturopath.

Treating underlying causes for adrenal fatigue, e.g. dietary issues/sensitivities, sex hormone imbalances low thyroid hormone levels, exercise and stress, are all involved in fixing the adrenal dysfunction occurring. Issues such as a sex hormone imbalance, leaky gut, high thyroid antibodies, diet and food sensitivities are often the root cause behind adrenal fatigue but you have to figure out what it is for you. All of them were behind mine.

You can click on the hyperlinks in the above post to learn more and see references to information given, but more reading and references can also be found at:


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Written by Rachel, The Invisible Hypothyroidism

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