Hashimoto’s Encephalopathy

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The diagnosis of Hashimoto’s Encephalopathy can be quite a scary and daunting experience. If you haven’t heard of it before, it’s important to be aware of the signs and symptoms. 

What is Hashimoto’s Encephalopathy?

The term Encephalopathy refers to when the brain changes due to damage, disease, or a disorder.

Hashimoto encephalopathy is a rare condition characterised by the onset of confusion, altered levels of consciousness, jerking muscles, seizures and other, often scary, mental changes. However, the symptoms can differ from person to person.

It is usually diagnosed when someone presents with the symptoms of it, whilst thyroid testing also shows subclinical hypothyroidism or overt hypothyroidism, along with positive thyroid antibody tests over range (Thyroid Peroxidase and Thyroglobulin).

What Causes Hashimoto’s Encephalopathy?

In most cases, the cause is unfortunately unknown, but is thought to involve an autoimmune or inflammatory abnormality, and it associated with Hashimoto’s Thyroiditis, which is the most common cause of hypothyroidism, at around 90%.

However, the relationship between the two is still quite unclear. It doesn’t appear to be directly related to hypothyroidism, interestingly. Experts in the field recommend that cases of Hashimoto’s encephalopathy should be classified as ‘probable’ autoimmune encephalitis.

However, some scientists think that, like Hashimoto’s Thyroiditis, Hashimoto’s encephalopathy could be an autoimmune disease, meaning that it is caused by the immune system mistakingly attacking the brain for destruction.

Onset of Hashimoto encephalopathy seems to occur most often from 40-45 years old.

The condition is considered to be very rare indeed, with estimations of 2.1 people in 100,000 to have it. However, more people may be going undiagnosed or misdiagnosed due to the condition not being well-understood or highly recognised. And the symptoms are very similar to many other conditions.

What is The Treatment for Hashimoto’s Encephalopathy?

Corticosteroid therapy is often used and most people respond well to this, or other immunosuppressive therapies, with symptoms tending to resolve or improve greatly within a few months. [1]

Also managing and treating the hypothyroidism and thyroid antibodies is recommended too. Unfortunately, it isn’t considered curable, but prognosis following treatment is usually good.  After initial treatment however, the patient may relapse and require it again.

You can click on the hyperlinks in the above post to learn more and see references to information given.

References:

[1] Devon I Rubin, Hashimoto’s encephalopathy. UpToDate. Waltham, MA: UpToDate; September, 2014

http://www.hesaonline.org/what_is_he/

http://www.hesaonline.org/scientific-research/

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Written by Rachel, The Invisible Hypothyroidism

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